Clinical laboratory International (CLI)

The leading international magazine for Clinical laboratory Equipment for everyone in the in vitro diagnostics field and related disciplines.

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Featured Articles

Rapid, point-of-care device allows fast analysis of urinary cystatin C to monitor kidney function in low-resource settings

Functions of the kidneys The kidneys are complex and delicate organs that perform a number of roles. In addition to the function that we all associate them with of filtering and excreting waste products from the blood (notably urea from protein breakdown and creatinine from muscle use), they also regulate fluid and water balance to […]

NELL1 A novel autoantibody in membranous nephropathy

by Dr Jacqueline Gosink Membranous nephropathy (MN) is associated with autoantibodies against glomerular antigens, most notably M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A). Recently, neural epidermal growth factor-like protein (NELL1) was identified as an additional target antigen, defining a distinct form of MN. NELL-1-associated MN appears to be the second most […]

Understanding patterns of rheumatic disease trajectory and treatment response

There are number of rheumatic diseases that have similar and overlapping sets of symptoms that make them challenging to diagnose correctly in the first instance. Additionally, patients can have different disease trajectories and respond differently to different drug therapies. Machine learning data analysis has helped to define different subgroups of patients either at baseline or […]

Analysis of type I and II interferons in human immunity and pathology

Interferons are among the key regulators of the immune response. However, in excess, they are linked to autoimmune and autoinflammatory diseases, but accurate and timely measurement of interferon levels can be challenging, depending on accessibility. CLI chatted to Dr Roshini Abraham (Nationwide Children’s Hospital, Columbus, Ohio, USA) to find out more about these cytokines and […]

E-News

Undecimal Bio launches with oversubscribed seed round to take siRNA delivery beyond the liver

Undecimal Bio, a platform biotechnology company advancing targeted delivery of siRNA therapeutics, has launched with an oversubscribed $18 million (about €16.2 million) seed financing. The company, a spin-out from Eleven Therapeutics, will use the funding to expand DELiveri®, its proprietary AI-enabled platform for identifying conjugates that can direct RNA medicines to defined cell types, addressing […]

Astoriom acquires Sampled’s UK stability storage business

Astoriom, a global leader in sample stability and biorepository storage for scientific research and consumer products, has acquired Roylance Stability Storage Limited and Roylance Scientific Limited. The two companies are the UK operations of life sciences stability storage provider Sampled and are based in Glasgow. Astoriom said the deal broadens its coverage, adds technical expertise […]

United Immunity signs clinical supply agreement with Roche for UI-102 combination studies

United Immunity, Co., Ltd., a clinical-stage biotechnology company in Tokyo, Japan, advancing next-generation immunotherapies through its proprietary Myeloid Targeting Platform™, has entered into a Master Clinical Supply Agreement with Roche. The agreement covers the supply of atezolizumab (Tecentriq®), a humanised anti-PD-L1 monoclonal antibody checkpoint inhibitor, and will support future clinical studies evaluating UI-102, a TLR7/8 […]

Shift Bioscience publishes calibration framework to improve reliability of AI virtual cell models

Shift Bioscience, a Cambridge, UK, biotechnology company uncovering the biology of cell rejuvenation to develop new therapies for age-driven diseases, has announced the publication of new research in Nature Biotechnology [1]. The peer-reviewed study describes an improved calibration framework for deep learning-based genetic perturbation models, a type of AI virtual cell.

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