Certified solutions of thyroid hormones
Certified Snap-N-Spike solutions of thyroid hormones T4, T3, and reverse T3 are now available at concentrations of 100 µg/mL in 0.1 N ammonia in methanol for each solution standard. These Certified Spiking Solutions are suitable for use as critical starting materials in preparation of calibrators, controls, or linearity standards for analytical testing including LC-MS/MS analysis of free and total thyroid hormone levels. Analytical challenges in thyroid hormone testing range from standardization of free thyroid hormone testing methods to agreement in value assignment of the calibrator concentration. With the push towards developing LC-MS/MS laboratory developed tests (LDTs), the need for highly accurate certified reference materials has significantly increased. Accuracy in the concentration of thyroid hormone calibrators and controls, for example, are complicated by the presence of residual impurities of not only water, solvent and inorganic but also other thyroid hormones in the reference material. Any significant difference in purity of the thyroid hormone reference material or its impurity profile from lot-to-lot could increase variability and impact the test’s accuracy and reproducibility. With thyroid hormones it is critical to use fully characterized compounds because some of the impurities present in each hormone are the other hormones of interest. Cerilliant Certified Spiking Solutions are prepared and certified to the highest industry standards including ISO Guide 34 and ISO 17025. Comprehensive certificates of analysis (COAs) are provided for every Cerilliant certified reference standard and include all analytical data from full neat material characterization and solution standard verification to uncertainty and traceability information for a laboratory’s regulatory requirements. COAs for the thyroid hormone Certified Spiking Solutions also identify T1, T2, T3, reverse T3 or T4 if present in the certified reference material.
Supplier: Cerilliant Corp.
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